Viccillin-SX 1500 Drug Interactions

Probenecid decreases the renal tubular secretion of ampicillin and sulbactam. Concurrent use of probenecid with Viccillin-SX 1500 may result in increased and prolonged blood levels of ampicillin and sulbactam. The concurrent administration of allopurinol and ampicillin increases substantially the incidence of rashes in patients receiving both drugs compared to patients receiving ampicillin alone. It is not known whether this potentiation of ampicillin rashes is due to allopurinol or the hyperuricemia present in these patients. There are no data with Viccillin-SX 1500 and allopurinol administered concurrently, Viccillin-SX 1500 and allopurinol aminoglycosides should not be reconstituted together due to the in vitro inactivation of aminoglycosides by the ampicillin component of Viccillin-SX 1500.
Administration of Viccillin-SX 1500 will result in high urine concentration of ampicillin. High urine concentrations of ampicillin may result in false-positive reactions when testing for presence of glucose in urine using Clinitest, Benedict's solution or Fehling's solution. It is recommended that glucose based on enzymatic glucose oxidase reactions (eg, clinistix or tes-tape) be used. Following administration of ampicillin to pregnant women, a transient decrease in plasma concentration of total conjugated estriol, estriol-glucoronide, conjugated estrone and estradiol has been noted. This effect may also occur with Viccillin-SX 1500.
Stability and Compatibility: Sulbactam sodium is compatible with most IV solutions but ampicillin sodium and hence Viccillin-SX 1500 powder for injection is less stable in solutions containing dextrose or other carbohydrates and should not be mixed with blood products or protein hydrolysates. Ampicillin and hence Viccillin-SX 1500 powder for injection is incompatible with aminoglycosides and should not be physically mixed in the same container. The concentrated solution for IM administration should be used within 1 hr of reconstitution. Time periods for use in different diluents for IV infusion are as follows (see Table 3).


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